Vitamin E – Fertlit E, Immunit E and Vitalit E

Eight types of compounds, four tocopherols and four tocotrienols, clustered in a single group is all about Vitamin E. Initially assumed as a single entity and termed as tocopherol for its essential role in fertility, Vitamin E is now, scientifically established to have manifold biological activity. Of all the vitamin E types, gamma-tocopherol is the most common dietary form and alpha-tocopherol is the most active biologically (Reboul et al, 2006).

Wheat germ oil, sunflower oil, soybean oil, almonds, peanuts, spinach, pumpkin, asparagus, mango, and avocado are abundant sources of Vitamin E. The Recommended Dietary Allowance (RDA) for vitamin E for those older than fourteen years of age is 15 mg a day equivalent to 22 international units. The RDA holds good for men and women, including those in their pregnancy. A daily dose of 19 mg equivalent to 28 international units is the RDA for lactating mothers. 

Reduced fecundity, and fertility, retinal damage, an affliction of the peripheral nerves, loss of control over body movements, muscular weakness, and diminished immune function are some of the common symptoms of E deficiency (Hercberg et al, 2004).

Biological Benefits

Vitamin E -a Known Antioxidant

Vitamin E is capable of penetration into biological membranes and an excellent fat-soluble antioxidant, protecting cell membranes from reactive free radicals. The ‘’chromane double ring’’ present in all the types of Vitamin E discussed, can reduce free radicals in the cell.

Vitamin E and Cardiovascular Health

Research studies have documented a twenty to forty percent reduction in cardiovascular adverse events in those on vitamin E supplementation for at least two years (Rimm et al, 2000). Clinical trials have shown a twenty four percent reduction in cardiovascular risks amongst women on Vitamin E supplementation (Lee et al, 2005). 

The reduction has been shown to be up to twenty six percent among those beyond sixty-five years of age or more, with decreased events of vascular blood clots (Glynn et al, 2007).

Vitamin E in Cancer Prevention

A few observational studies and clinical trials have indicated a reduced risk of advanced prostate cancer in a cohort of smokers with Vitamin E supplements (Chan et al, 1999).

Vitamin E in Geriatric Health

A six-year clinical study has established that vitamin E, in combination with vitamin C, beta carotene, and zinc, can reduce the incidence of AMD (Advanced Age-Related Macular Degeneration) (ARED, 2001 and 2007). 

Vitamin E supplementation has been shown to reduce risk of the onset of Sporadic Amyotrophic Lateral Sclerosis (ALS), a neurodegenerative neuromuscular disease that results in the progressive loss of motor neurons that control voluntary muscles (Kerman et al, 2011). A recent collective analysis of multiple studies on ALS with more than 1 million participants has shown that the longer the use of vitamin E supplements, lower the risk of onset of ALS (Ascherio et al, 2005). Though clinical trials of vitamin E supplements in the ALS afflicted cohort have not shown any cure, Vitamin E has proven beneficial in delaying the onset of age-related ALS (Wang et al, 2011). 

Research studies in 2005 have concluded that diets higher in vitamin E content lowers the risk of developing Parkinson's Disease also known as the ‘’older person's disease’’ a common neuro-degenerative disease diagnosed in people over age sixty (Etminan et al, 2005).

Vitamin E for Liver Diseases

Alpha-tocopherol has been shown to be effective in the treatment of Non-Alcoholic Fatty Liver Disease (NAFLD), especially the severe extreme type of the disease known as Non-Alcoholic Steatohepatitis (NASH). Controlled clinical trials, have also established the physiological role of vitamin E in the reduction of abnormal levels of liver enzymes, abnormal retention of fat in cells, inflammation, and fibrotic scarring in tissues (Sato et al, 2015).

Vitamin E in Pregnancy

Alpha-tocopherol intake has been recommended to be effectual for reducing risk of stillbirth, neonatal death, preterm birth, preeclampsia, and other pregnancy complications (Rumbold et al, 2015).

Vitamin E and Wound Healing

Tocopheryl acetate has been in use as a topical medicine, for wound healing and scar reduction (Panin et al, 2004).


Alpha-tocopherol has known interactions with drugs like aspirin, warfarin, tamoxifen, and cyclosporine A. Clinical trials have demonstrated a reduction in blood concentration of the anti-breast cancer drug tamoxifen at 400 mg/day dose of Vitamin E (Podszun et al 2014). Hence, it is good to take the recommendations of a health care provider to decide upon the correct daily dose of Vitamin E.

This Article was written by one of our Guest bloggers Professor B.V. Ramanan Consultant Microbiologist.

This article is not intended to Diagnose or treat any disease or illness, If you are having health concerns please speak with your Doctor.


  1. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8. Arch Ophthalmol. 2001; 119:1417-36.

  2. Age Related Eye Disease Study 2 (AREDS2). National Eye Institute, 2007. Accessed 8 November 2007.

  3. Ascherio A, Weisskopf MG, O’Reilly E J, et al. Vitamin E intake and risk of amyotrophic lateral sclerosis. Ann Neurol. 2005; 57:104-10.

  4. Chan JM, Stampfer MJ, Ma J, Rimm EB, Willett WC, Giovannucci EL. Supplemental vitamin E intake and prostate cancer risk in a large cohort of men in the United States. Cancer Epidemiol Biomarkers Prev. 1999; 8:893-9.

  5. Etminan M, Gill SS, Samii A (June 2005). "Intake of vitamin E, vitamin C, and carotenoids and the risk of Parkinson's disease: a meta-analysis". The Lancet. Neurology. 4 (6): 362–5. doi:10.1016/S1474-4422(05)70097-1

  6. Glynn RJ, Ridker PM, Goldhaber SZ, Zee RY, Buring JE. Effects of random allocation to vitamin E supplementation on the occurrence of venous thromboembolism: report from the Women’s Health Study. Circulation. 2007; 116:1497-503.

  7. Hercberg S, Galan P, Preziosi P, et al. The SU.VI.MAX Study: a randomized, placebo-controlled trial of the health effects of antioxidant vitamins and minerals. Arch Intern Med. 2004; 164:2335-42.

  8. Kiernan MC, Vucic S, Cheah BC, Turner MR, Eisen A, Hardiman O, Burrell JR, Zoing MC (March 2011). "Amyotrophic lateral sclerosis". Lancet. 377 (9769): 942–55. doi:10.1016/s0140-6736(10)61156-7

  9. Lee IM, Cook NR, Gaziano JM, et al. Vitamin E in the primary prevention of cardiovascular disease and cancer: the Women’s Health Study: a randomized controlled trial. JAMA. 2005; 294:56-65.

  10. Panin G, Strumia R, Ursini F (December 2004). "Topical alpha-tocopherol acetate in the bulk phase: eight years of experience in skin treatment". Annals of the New York Academy of Sciences. 1031 (1): 443–7. Bibcode:2004NYASA1031

  11. Podszun M, Frank J (December 2014). "Vitamin E-drug interactions: molecular basis and clinical relevance". Nutrition Research Reviews. 27 (2): 215–31.

  12. Reboul E, Richelle M, Perrot E, Desmoulins-Malezet C, Pirisi V, Borel P (November 2006). "Bioaccessibility of carotenoids and vitamin E from their main dietary sources". Journal of Agricultural and Food Chemistry. 54 (23): 8749–55.

  13. Rimm EB, Stampfer MJ. Antioxidants for vascular disease. Med Clin North Am. 2000; 84:239-49.

  14. Rumbold A, Ota E, Hori H, Miyazaki C, Crowther CA (September 2015). "Vitamin E supplementation in pregnancy". The Cochrane Database of Systematic Reviews (9): CD004069. doi:10.1002/14651858.CD004069.

  15. Sato K, Gosho M, Yamamoto T, Kobayashi Y, Ishii N, Ohashi T, et al. (2015). "Vitamin E has a beneficial effect on nonalcoholic fatty liver disease: a meta-analysis of randomized controlled trials". Nutrition. 31 (7–8): 923–30

  16. Wang H, O’Reilly EJ, Weisskopf MG, et al. Vitamin E intake and risk of amyotrophic lateral sclerosis: a pooled analysis of data from 5 prospective cohort studies. Am J Epidemiol. 2011; 173:595-602.

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