RHEUM RHAPONTICUM root extract (5% rhaponticin, providing 7.5 mg rhaponticin), has been shown in the research to be helpful with many of the symptoms of perimenopausal and menopausal women, including hot flashes, mood lability, anxiety, irritability, vaginal dryness, and fatigue. It is believed to have its effect, like many phytoestrogens, by having a weak binding affinity for estrogen receptors, both a and ß. The long-term safety, including the lack of proliferative uterine stimulation, and efficacy of this ingredient has also been established in multiple long-term studies.