What is Niacin?
Niacin, also known as vitamin B3, is a micronutrient with a
40-year history of efficacy in supporting healthy lipid levels,
especially high-density lipoprotein cholesterol (HDL-C)
levels. However, one side effect often makes supplementing
niacin a less than pleasurable experience, limiting adherence.
Some patients experience flushing when supplementing
niacin. However, a properly- manufactured, sustainedrelease
niacin circumvents this side effect. By using a
proprietary, natural wax-matrix coating technology, Time
Release Niacin is released slowly over a six- to eight-hour
period to reduce flushing. This time period is considered
the ideal window for releasing equal amounts of niacin into
circulation as nicotinuric acid, the beneficial metabolite
responsible for niacin’s lipid balancing benefits.[1-2] In a
double-blind placebo-controlled study, this specific form of
Time Release Niacin had only a 5-7 % flush rate, making it
well-tolerated and highly effective for supporting balanced
Niacin is required by the body to promote the health and
function of the digestive system, liver, skin and nerves. [3-4] It
also plays a role in converting food to energy. Niacin is found
in dairy products, eggs, grains, fish, lean meats, nuts and
legumes. It is a water-soluble vitamin, meaning that excess is
excreted through the urine and continuous dietary intake is
necessary to support optimal health.
Niacin is most known for its broad cardiovascular benefits,
but is also an important nutrient for bone health, blood sugar
balance and cerebrovascular function.[5-9] Populations that
consume adequate levels of niacin have been shown to have
better outcomes for long-term health. 
Symptoms of mild deficiency of niacin may include indigestion,
fatigue, canker sores and depression. Niacin deficiency, if left
unattended, can negatively affect brain function leading to
apathy, fatigue, disorientation and memory loss.
Cardiovascular Health and Cholesterol Balance†
Niacin has been used since the 1950s to maintain healthy
balance of cholesterol levels. Since 1978, researchers have
labeled niacin a “front-line” nutrient for cardiovascular support. 
The National Cholesterol Education Program (NCEP) panel
designated niacin a “first-line therapy” for support of specific
parameters related to balancing cholesterol levels in 1988,
further emphasizing the micronutrient’s safety and importance
in cardiovascular health. Other studies have shown niacin to
enhance long-term cardiovascular health. [7-10]
When taken at doses greater than the Recommended Daily
Amount (RDA), niacin:
- Promotes healthy high-density lipoprotein (HDL) levels
already within the normal range by 20-35%. No other nutrient
or compound has been shown to be as effective in supporting
healthy HDL levels.
- Maintains healthy lipid particle size. Small low-density
lipoprotein (small LDL) particles are an important yet
underappreciated marker of cardiovascular function. Niacin is the
most effective agent known for supporting a normal cholesterol
- Supports healthy triglycerides levels. Niacin is especially
effective when taken with fish oil (at doses of 1,500-3,000 mg of
- Supports normal very low-density lipoprotein (VLDL)
- Supports healthy lipoprotein(a), or Lp(a) levels. No other
treatment approaches the power of niacin to promote healthy
Lp(a) levels, which is among the most important markers of heart
- Promotes low-density lipoprotein (LDL) balance.
Niacin supports lipid balance by blocking the release of fatty
acids from fat cells. Fewer fatty acids are passed through to the
liver, resulting in fewer VLDL particles. Less VLDL leads to less
small LDL and higher HDL. To the benefit of the cardiovascular
system, niacin also improves endothelial function and nitric
oxide synthase activity which protects blood vessels and
promotes healthy circulation.
1 tablet three times per day with a meal or as recommended by
your health care professional.
Does Not Contain
Gluten, corn, yeast, artificial colors and flavors.
If you are pregnant or nursing, consult your physician before
taking this product. This product is designed to release niacin
over a six- to eight- hour period to minimize flushing (Avoiding
hot beverages is recommended). A small percentage of people
may still experience harmless flushing while taking this product.
1. Keenan JM, Fontaine PL et al. Niacin revisited. A
randomized, controlled trial of wax-matrix sustainedrelease
niacin in hypercholesterolemia. Arch Intern Med. 1991
2. Keenan JM,Bae CY et al.Treatment
of hypercholesterolemia: comparison of younger versus older
patients using wax-matrix sustained-release niacin. J Am Geriatr
Soc. 1992; 40(1):12-8.
3. Bissett DL, Oblong JE, Berge CA, et al. Niacinamide:
A B vitamin that improves aging facial skin appearance. Dermatol
Surg. 2005;31:860-865; discussion 865.
4. Benavente CA, Jacobson MK, Jacobson EL. NAD in
skin: therapeutic approaches for niacin. Currr Pharm Des.
5. Elam M, Hunninghake DB, Davis KB, et al. Effects of
niacin on lipid and lipoprotein levels and glycemic control in
patients with diabetes and peripheral arterial disease: the ADMIT
study: a randomized trial. Arterial Disease Multiple Intervention
Trial. JAMA. 2000;284:1263-1270.
6. Canner PL, Furberg CD, Terrin ML, McGovern ME.
Benefits of niacin by glycemic status in patients with healed
myocardial infarction (from the Coronary Drug Project). Am J
Cardiol. 2005; 95(2):254-7.
7. Guyton JR. Niacin in cardiovascular prevention:
mechanisms, efficacy, and safety. Curr Opin Lipidol. 2007
8. McKenney J. New perspectives on the use of
niacin in the treatment of lipid disorders. Arch Intern Med. 2004
9. Morgan JM,Carey CM,Lincoff A,Capuzzi DM. The
effects of niacin on lipoprotein subclass distribution. Prev Cardiol.
10. AIM-HIGH Investigators. The role of niacin in
raising high-density lipoprotein cholesterol to reduce
cardiovascular events in patients with atherosclerotic
cardiovascular disease and optimally treated low-density
lipoprotein cholesterol Rationale and study design. The
Atherothrombosis Intervention in Metabolic syndrome with low
HDL/high triglycerides: Impact on Global Health outcomes (AIMHIGH).
Am Heart J. 2011 Mar;161(3):471-477.e2.
11. Kannel WB. Recent findings from the Framingham
study—I. Med Times. 1978 Apr;106(4):23-27
12. Hulley SB. The US National Cholesterol Education
Program. Adult treatment guidelines. Drugs. 1988;36 Suppl