Thyrotain is a comprehensive formulation that provides
a blend of nutrients and botanicals working in synergy
to support thyroid health.
Thyrotain includes L-tyrosine
and iodine, which make up the backbone of the thyroid
hormones thyroxine (T4) and triiodothyronine (T3). The
addition of zinc, copper, selenium, vitamin A, and the
botanical guggulipid activate enzymes that enhance
the conversion of T4 into the active thyroid hormone T3.
Vitamin A and zinc also help improve cellular sensitivity to
thyroid hormones. Turmeric, along with the antioxidants
vitamin C and E and N-acetyl cysteine (NAC), provide a
powerful combination of antioxidants that boost thyroid
health by reducing free radical stress.
The thyroid gland, located in the neck below the Adam’s apple,
produces T4 and T3 hormones that regulate cell metabolism.
In this process, thyroxine is converted into the metabolically
active hormone T3. Thyroid hormones are required for
mitochondrial metabolism in every cell in the body. Therefore,
a deficiency of thyroid hormones can affect virtually all bodily
functions, including metabolic rate, reproduction, hormone
production, and brain function, as well as musculoskeletal,
psychological and cardiovascular health.1
Lifestyle factors, environmental toxins and nutrient deficiencies
can negatively impact thyroid hormone production. A number
of nutrients are required to produce thyroid hormones and to
help convert T4 into T3. These nutrients include L-tyrosine,
iodine, selenium, zinc and vitamin A. A deficiency in any of
these nutrients can cause the thyroid to under-function. Heavy
metals, such as mercury, lead and cadmium, as well as other
chemical contaminants, can also block the conversion of
T4 to T3. In addition, long-term stress can lead to increased
production of the adrenal hormone cortisol. Excessive levels
of cortisol can block the conversion of T4 to T3 and also
increase the production of reverse T3 (RT3). RT3 is an isomer of
triiodothyronine that competes with T3 at the receptor sites.
Conversely, exercise positively impacts the thyroid gland by
stimulating hormone secretion and increasing tissue sensitivity
to thyroid hormones.1 (See Figure 1).
Vitamins and Minerals †
Thyroid hormones are made from amino acid L-tyrosine and
iodine. Iodine is an essential trace mineral and is necessary
for the synthesis of thyroid hormones, as it is one of the most
important components of the hormones T4 and T3. The
thyroid gland absorbs iodine from the blood and incorporates
it into thyroid hormones. In addition to supporting thyroid
hormone production, research shows iodine acts as an
antioxidant, supporting a healthy thyroid gland and protecting
a variety of tissues, including mammary tissue, the eyes and
Normal thyroid status is dependent on adequate levels of many
trace minerals for the synthesis and metabolism of thyroid
hormones. The minerals zinc, copper and selenium are required
cofactors for the enzymes that convert T4 to T3. Selenium
deficiency has been shown to contribute to decreased T4 to T3
Supplementation of selenium can also help decrease
thyroperoxidase (TPO) antibodies in thyroid autoimmunity.3
Supplementation with zinc has been shown to restore T3 levels in
patients with normal T4 and low T3, demonstrating its role in the
Vitamin A and vitamin E are also necessary for
normal thyroid hormone manufacturing.
Antioxidants (Turmeric, Vitamins C and E, and
Increased free radical activity can compromise healthy T4 to
T3 conversion. N-acetyl cysteine (NAC), a precursor to the
body’s master antioxidant glutathione, boosts thyroid health
by accelerating antioxidant activity in the thyroid gland. In
a randomized, multicenter clinical trial, the effects of NAC
administration were examined in patients with low T3 and high
RT3 levels. RT3 decreased in a time-dependent fashion in NACtreated
patients, whereas no significant changes in serum RT3
levels were observed in the placebo group. Additionally, the T3
to RT3 ratio increased progressively in NAC-treated patients,
whereas no changes were seen in the placebo group.5
Turmeric (Curcuma longa), along with the antioxidants vitamin
C and E, has been shown to promote a healthy thyroid gland
due to direct antioxidant activity. In animal studies, turmeric
and these antioxidants were studied to observe the protective
effects on thyroid health. In this study, rats that had been
treated with a chemical that increased thyroid weights showed
decreased T4 and T3 as compared to controls. In the treatment
group, rats receiving vitamin C, E and turmeric showed
reduced weights in the thyroid gland and less suppression of
T4 and T3 levels. The researchers suggested that the positive
effects of the curcumin, vitamin C and vitamin E combination
could be due to the direct involvement of antioxidants in the
thyroid gland. 6
Ashwagandha (Withania somnifera) has been used in
Aryuvedic and indigenous medical systems for over 3,000
years and has been examined in research studies for its stresslowering
Ashwagandha has been found to exhibit
GABA agonist activity, which accounts for its ability to relax
the nervous system. Ashwagandha may also stimulate thyroid
activity indirectly, via its effects on cellular antioxidant systems,
specifically by increasing the antioxidant enzymes superoxide
dismutase and catalase and reducing lipid peroxidation.8
studies using mice, the effects of administration of Withania
somnifera root extract (1.4 g/kg of body weight for 20 days)
demonstrated an increase in serum T4 concentrations.8,9
Guggulipid (Commiphora mukul)
The gum resin of the guggul plant has been used in Ayurvedic
medicine in India for nearly 3,000 years. Guggulipid has been
shown to support thyroid function, primarily by decreasing lipid
peroxidation in the liver, the principal site of T3 generation. Guggul
extract has also been shown to have thyroid-stimulating action by
increasing iodine uptake by the thyroid gland and increasing the
activities of thyroid peroxidase and protease.10,11 In animal studies
using mice, the effects of guggulu, the gum resin of Commiphora
mukul, were examined. A chemical that induced hypothyroidism
was administered simultaneously along with guggulu (200 mg/
kg of body weight per day for 30 days). In this study, it was found
that treatment with guggulu decreased lipid peroxidation while
increasing the activity of sodium oxidase dismutase and catalase.12
4 capsules per day or as recommended by your health care
Does Not Contain
Gluten, artificial colors and flavors.
Do not consume this product if you are pregnant or nursing.
Consult your physician for further information.
1. Pizzorno JE, Murray MT (2013). Textbook of Natural
Medicine (4th edition). St. Louis: Churchill Livingstone.
2. Dunn JT. What’s happening to our iodine? Clin Endocrinol
Metab 1998;83: 3398-3400.
3. Pizzorno JE, Murray MT. The Clinician’s Handbook of
Natural Medicine. 2nd Ed. 2008.
4. Nishiyama S, Futagoishi-Suginohara Y, Matsukura M,
Nakamura T, Higashi A, Shinohara M, Matsuda I. Zinc
supplementation alters thyroid hormone metabolism in
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5. Vidart J, Wajner SM, Leite RS. N-acetylcysteine
administration prevents nonthyroidal illness syndrome in
patients with acute myocardial infarction: a randomized
clinical trial. J Clin Endocrinol Metab 2014;99(12):4537-45.
6. Deshpande UR, Joseph LJ, Patwardhan UN, Samuel AM.
Effect of antioxidants (vitamin C, E and turmeric extract) on
methimazole induced hypothyroidism in rats. Indian J Exp
Biol. 2002 Jun;40(6):735-8.
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effect of Withania somnifera glycowithanolides in chronic
footshock stress-induced perturbations of oxidative free
radical scavenging enzymes and lipid peroxidation in rat
frontal cortex and striatum. J Ethnopharmacol 2001, 74,1-6.
8. Panda S, Kar A. Changes in thyroid hormone concentrations
after administration of ashwagandha root extract to adult
male mice. J Pharm Pharmacol. 1998 Sep;50(9):1065-8.
9. Panda S, Kar A. Withania somnifera and Bauhinia purpurea
in the regulation of circulating thyroid hormone
concentrations in female mice. J Ethnopharmacol. 1999
10. Tripathi YB, Malhotra OP, Tripathi SN. Thyroid Stimulating
Action of Z-Guggulsterone Obtained from Commiphora
mukul. Planta Med. 1984 Feb;50(1):78-80.
11. Singh AK, Prasad GC, Tripathi SN. In vitro studies on
thyrogenic effect of commiphora mukul (guggulu). Anc Sci
Life. 1982 Jul-Sep; 2(1): 23–28.
12. Panda S, Kar A. Guggulu (commiphora mukul) potentially
ameliorates hypothyroidism in female mice. Phytother Res
2005 Jan; 19(1): 78-80.