What is Pregnenolone?
Pregnenolone plays a key role in hormonal balance as a key
precursor to cortisol, dehydroepiandrosterone (DHEA) and
progesterone, and helps to maintain balance in the body’s
stress response system. In addition, pregnenolone has been
shown to support a balanced mood and promote cognitive
health by modulating the transmission of messages between
neurons, influencing learning and memory processes. Since
there is strong evidence that pregnenolone levels diminish
with advancing age, restoring these levels may also help
support overall brain function and sense of well-being. Each
serving includes 10 mg of pregnenolone in a scored, quickdissolved
tablet, allowing for incremental dosing as needed.
Pregnenolone is a prohormone that is synthesized in the
brain and adrenals, but also in the liver, skin, brain, testicles,
ovaries, and retina. As a biochemical precursor to DHEA and
progesterone, pregnenolone helps maintain a normal balance
between these hormones in the body and as a result, helps to
modulate the cortisol-driven stress response system, support
nerve cell growth and modulate mood.
In addition to its function as a prohormone, pregnenolone is a
neurosteroid that is found in high concentrations in the brain
where it protects neurons, enhances myelination and supports
cognitive health and memory. Pregnenolone supplementation
is particularly important for those who have been found to
have deficient hormone levels through testing, as well as
those who need cortisol-to-DHEA ratio support.
Pregnenolone levels naturally peak during youth and begin a
long, slow decline with age. Since pregnenolone is the parent
compound of other vital neurosteroids such as DHEA,1
levels of pregnenolone could leave brain cells increasingly
vulnerable to overstimulation by neurotransmitters like
glutamate,1,2 thereby affecting mood and cognition.
Research has shown pregnenolone to be beneficial for mood
support and balance.3
Specifically, pregnenolone is reported
to have a positive effect on neuronal excitability and synaptic
plasticity, and has many other functions associated with mood
regulation, neuroprotection from free radicals, balancing the
stress response and improving cognitive performance.3
In a study of 15 adults with mood imbalance, blood levels
of pregnenolone were lower among those with low mood,
compared to controls.4
Among 70 adults with mood
imbalance who received either pregnenolone or placebo, the
pregnenolone group trended toward greater improvement
in mood, relative to the placebo group on rating scales.5
Additionally, an eight-week, double-blind, randomized,
placebo-controlled study that compared 30 mg/day or 200
mg/day pregnenolone, 400 mg/day of DHEA, and placebo
found those given the 30 mg pregnenolone had significant
reductions in positive symptom scores along with an
improvement in attention and working memory performance.
Further improvements were not found among groups given
higher amounts of pregnenolone.6
Learning and Memory†
Animal studies have demonstrated that both pregnenolone
and DHEA support learning and healthy memory among
the aging, initiated by balancing the activity of N-methyl-Daspartate
(NMDA) and gamma aminobutyric acid (GABA-A)
receptors.7,8 Infusions of pregnenolone have been found to
reverse memory deficits in animals, and the data suggests
pregnenolone increases neuron regeneration and positively
influences cognitive processes in senescent subjects, by
increasing acetylcholine levels improving neurotransmission.9
Additional studies have shown pregnenolone to enhance
neuritic outgrowth and growth of myelin, impart
neuroprotective effects against free radicals that increase
neurogenesis, promote healthy levels of inflammation,
modulate the stress response system and increase GABA-A
receptor responses. Pregnenolone administration has also
been shown to positively modulate NMDA receptors, offering
additional benefits for mental health.10
1 or more tablets per day or as recommended by your health
Does Not Contain
Gluten, yeast, artificial colors and flavors.
Do not consume this product if you are pregnant or nursing.
Consult your physician for further information.
1. Stomati M, Monteleone P, Casarosa E, et al. Six-month
oral dehydroepiandrosterone supplementation in early
and late postmenopause. Gynecol Endocrinol. 2000
2. Vallee M, Purdy RH, Mayo W, Koob GF, Le MM.
Neuroactive steroids: new biomarkers of cognitive aging. J
Steroid Biochem Mol Biol. 2003 Jun;85(2-5):329-35.
3. Ritsner, M. S. Pregnenolone, dehydroepiandrosterone,
and schizophrenia: alterations and clinical trials. CNS
Neurosci Ther. 2010; 16(1):32-44).
4. Ritsner M, Maayan R, Gibel A, Weizman A. Differences
in blood pregnenolone and dehydroepiandrosterone
levels between schizophrenia patients and healthy
subjects. Eur Neuropsychopharmacol. 2007 Apr;17(5):358-
5. Ritsner MS, Gibel A, Shleifer T, Boguslavsky I, Zayed
A, Maayan R, Weizman A, Lerner V. Pregnenolone and
dehydroepiandrosterone as an adjunctive treatment in
schizophrenia and schizoaffective disorder: an 8-week,
double-blind, randomized, controlled, 2-center, parallelgroup
trial. J Clin Psychiatry. 2010 Oct;71(10):1351-62.
6. Vallée M, Mayo W, Le Moal M. Role of pregnenolone,
dehydroepiandrosterone and their sulfate esters on
learning and memory in cognitive aging. Brain Res Brain
Res Rev. 2001 Nov;37(1-3):301-12.
7. Meziane H, Mathis C, Paul SM, Ungerer A. The
neurosteroid pregnenolone sulfate reduces learning
deficits induced by scopolamine and has promnestic
effects in mice performing an appetitive learning task.
Psychopharmacology (Berl). 1996 Aug;126(4):323-30.
8. Mayo W, Le Moal M, Abrous DN. Pregnenolone sulfate
and aging of cognitive functions: behavioral,
neurochemical, and morphological investigations. Horm
Behav. 2001 Sep;40(2):215-7.
9. Marx CE, Bradford DW, Hamer RM, Naylor JC, Allen
TB, Lieberman JA, Strauss JL, Kilts JD. Pregnenolone as a
novel therapeutic candidate in schizophrenia: emerging
preclinical and clinical evidence. Neuroscience. 2011 Sep
10. Wu FS, Gibbs TT, Farb DH. Pregnenolone sulfate: a
positive allosteric modulator at the N-methyl-D-aspartate
receptor. Mol Pharmacol. 1991 Sep;40(3):333-6.