Research has shown that phytosterols, plant-based
compounds structurally similar to cholesterol, compete
with cholesterol for absorption and thus play a key role
in supporting healthy cholesterol levels. According to the
Food and Drug Administration, “products containing at
least 0.65g per serving of plant sterol esters, taken twice
daily with meals for a daily total intake of at least 1.3g,
as part of a diet low in saturated fat and cholesterol, may
reduce the risk of heart disease.” The National Cholesterol
Education Program (NCEP) of the National Heart, Lung and
Blood Institute of Health suggest the use of plant sterols to
promote cardiovascular health. The Plant Sterols complex
includes a variety of purified plant sterols: campesterol,
stigmasterol, B-sitosterol and other cholesterol-like
compounds. Two capsules provide the recommended 1.3g
of plant sterol esters for maximum cardiovascular benefits.
Early historical diets were rich in phytosterols (they are present
in small amounts in grains, vegetables, fruits, legumes, nuts,
and seeds) providing as much as 1 g per day. Phytosterols
undergo absorption similar to that of cholesterol; both must
be incorporated into mixed micelles before being taken up by
enterocytes in the intestinal lining. Once inside the enterocyte,
the absorption of phytosterols is inhibited and they are
secreted back into the intestine at a much greater rate. During
this process, phytosterols displace cholesterol from food and
reduce cholesterol absorption, resulting in a beneficial effect
on blood cholesterol levels. In addition, the minimal amount
of phytosterols that are absorbed into the body, once taken
up by the liver , are rapidly secreted into bile by hepatic
transporters at a high rate, enhancing cholesterol excretion.
These mechanisms allow plant sterols to provide multispectrum
support for cardiovascular health and cholesterol
Both animal studies and dietary interventions have found that
the ingestion of plant sterols to be beneficial for cardiovascular
health. An intake of 2-2.5g per day of sterols have been
shown to significantly support healthy levels of blood fats in
two reviews on the subject.[5, 6] Sterol-enriched fermented milk
was also found to balance blood fats and increase the number
of patients achieving therapeutic targets, in a randomized,
double-blind, placebo controlled trial. A high intake of
naturally occurring plant sterols was found to be significantly
related to better cardiovascular health outcomes in men in a
population in Northern Sweden. Plant sterols given together
with fish oil has been found to have a synergistic effect in
balancing inflammatory markers.
1-2 capsules per day or as recommended by your health care
Does Not Contain
Gluten, corn, yeast, artificial colors and flavors.
If you are pregnant or nursing, consult your physician before
taking this product.
1. Yang, C., Yu, L. et al. Disruption of cholesterol homeostasis
by plant sterols. J Clin Invest. 2004; 114(6):813-822.
3. Sudhop T, Sahin Y, Lindenthal B, et al. Comparison of
the hepatic clearances of campesterol, sitosterol, and
cholesterol in healthy subjects suggests that efflux
transporters controlling intestinal sterol absorption also
regulate biliary secretion. Gut. 2002;51(6):860-863.
4. Silbernagel G, Genser B, Nestel P, März W. Plant sterols and
atherosclerosis. Curr Opin Lipidol. 2013 Feb;24(1):12-7.
5. Katan, M. B., Grundy, S. M. et al. Efficacy and safety of
plant stanols and sterols in the management of blood
cholesterol levels. Mayo Clin Proc. 2003; 78(8):965-978.
6. Demonty, I., Ras, R. T. et al. Continuous dose-response
relationship of the LDL-cholesterol-lowering effect of
phytosterol intake. J Nutr. 2009; 139(2):271-284.
7. Plana N, Nicolle C, Ferre R, Camps J, Cos R, Villoria J,
Masana L; DANACOL group. Plant sterol-enriched
fermented milk enhances the attainment of LDL-cholesterol
goal in hypercholesterolemic subjects. Eur J Nutr. 2008
8. Klingberg S, Ellegård L, Johansson I, Jansson JH, Hallmans
G, Winkvist A. Dietary Intake of Naturally Occurring Plant
Sterols Is Related to a Lower Risk of a First Myocardial
Infarction in Men but Not in Women in Northern Sweden. J
Nutr. 2013 Aug 7.
9. Micallef, M. A. and Garg, M. L. Anti-inflammatory and
cardioprotective effects of n-3 polyunsaturated fatty
acids and plant sterols in hyperlipidemic individuals.
Atherosclerosis. 2009; 204(2):476-482.