PhytoCore by Ortho Molecular Products
PhytoCore was created as part of the Core Restore Kit.
The specialized blend of nutrients in PhytoCore has been
shown to stimulate Phase I and II biotransformation and
support the body’s natural liver cleansing function during
detoxification. Each capsule includes silymarin (milk
thistle seed extract), artichoke leaf extract, turmeric root
extract, methionine, choline, inositol, garlic and dandelion
root extract. These botanicals and plant extracts contain
phytonutrients, antioxidants and other compounds shown
to increase cellular defenses, up-regulate detoxification,
and protect DNA.
The human body is exposed to a wide variety of toxins on a
daily basis, including chemicals found in foods, environmental
toxins and pharmaceuticals. The liver is the body’s main
detoxification organ, and provides enzyme systems that safely
process and remove xenobiotics and unhealthy hormone
metabolites out of the body. These detoxification systems are
very complex and require a variety of nutrients for
There are two main pathways of detoxification in the liver,
known as Phase I and Phase II. Phase I, composed mainly of
cytochrome P450 enzymes, involves non-reactive compounds
undergo specific reactions which use oxygen to form a
reactive site on the compound. Most pharmaceuticals are
metabolized through Phase I biotransformation. This prepares
the metabolite for the next step of detoxification, known as
Phase II. Phase II is a crucial step- if molecules from Phase I are
not fully metabolized by Phase II conjugation, they may cause
free radical damage to proteins, RNA and DNA within the cell.
Phase II reactions result in the biotransformation of fat-soluble
compounds into water-soluble compounds that can then be
excreted in the urine, bile or stool. PhytoCore’s botanicals and
plant extracts contain phytonutrients, antioxidants and other
compounds that naturally protect plants from environmental
challenges including exposure to radiation, toxins and
infectious agents. In humans, these biologically active
compounds have been shown to increase cellular defenses,
up-regulate liver detoxification pathways and protect DNA.[1,2]
Silymarin (Milk Thistle Seed Extract)†
Milk thistle (Silybum marianum) is an annual plant indigenous to
Europe and the United States and has been used for centuries
as a botanical medicine to support liver health. S. marianum
contains silymarin, the biologically active component found
in the seeds and leaves of this plant. Silymarin provides liverprotective
effects via several mechanisms of action including
inhibiting lipid peroxidation, supporting liver detoxification
through enhancement of the liver’s glucuronidation
pathways, and protection against glutathione depletion.
Silymarin has been shown to increase hepatocyte protein
synthesis resulting in enhanced detoxification function.
Artichoke Leaf Extract†
Artichoke is one of the oldest cultivated plants. The ancient
Greeks and Romans considered artichoke to be a valuable
digestive aid. In traditional European medicine, the leaves
of the artichoke were used as a diuretic to stimulate the
kidneys and as a choleretic to stimulate the flow of bile from
the liver and gallbladder. Artichoke leaf extracts have been
shown to provide antioxidant and liver support, including
the maintenance of healthy cholesterol levels and the
prevention of lipid oxidation. In a double-blind cross-over study in 20 subjects, artichoke extract was shown to increase
bile secretion. Animal studies have shown that artichoke
protected liver cells against oxidative stress and prevented
loss of glutathione. [8-10]
Turmeric Root Extract (Curcumin)†
Curcumin, the active compound in turmeric, an orangecolored
spice used for thousands of years in cooking and
medicine, has been shown to support the body’s antioxidant
and detoxification pathways. Curcumin elevates cellular levels
of glutathione, one of the body’s major antioxidants that
protects cells against free radical damage. Curcumin has
been shown to increase glutathione S-transferase (a phase
II detoxification enzyme), as well as the enzymes superoxide
dismutase (SOD), catalase, and glutathione peroxidase which
results in a significant increase in a variety of antioxidant
defenses. In a study examining the effects of curcumin
on cells loaded with arsenic, curcumin effectively counteracted
the effects of arsenic by increasing the activity of the
primary detoxification enzymes SOD, catalase and glutathione
Garlic is a well-known spice with a number of healthpromoting
properties. In addition to its cardio-protective
and immune supporting effects, garlic also plays a role in
supporting detoxification and antioxidant pathways. In
an animal study, the effects of garlic on hepatic cells were
examined following exposure to the toxic heavy metal, arsenic.
Arsenic administration resulted in generation of free radicals,
specifically reactive oxygen species (ROS), which caused cell
damage. The ROS generation in hepatic tissue reverted to
normal values following the administration of garlic extract
indicating the strong liver-protecting effect of garlic. 
Dandelion Root Extract†
Dandelion (Taraxacum officinale) is a native plant to the United
States and Europe, where the leaves and roots have been
used as food and herbal medicine. The German Commission
E and European Scientific Cooperative for Phytotherapy have
approved the use of dandelion root to support hepatic and
biliary function. Studies conducted in animals, have shown that
dandelion root increases bile secretion as well as glutathione
peroxidase, glutathione reductase and SOD. [14, 15]
Methionine and Choline†
Studies have shown that the nutrients methionine and choline
play a significant role in supporting normal liver cell function.
Methionine and choline act as lipotropic agents which aid in
fat metabolism as well as mobilization of fat out of the liver.
Studies using mice fed a diet deficient in methionine and
choline were found to have increased fatty acid uptake and
decreased very-low-density lipoprotein (VLDL) secretion. In a
study examining the effects of choline in 60 men it was found
that consumption of 550 mg of choline per day supported
the health and function of the liver, as assessed by measuring
serum alanine aminotransferase concentrations. 
Beet leaf (Beta vulgaris) has been used traditionally to help
support liver function. Research has shown that beets are
an excellent source of the nutrient betaine. Betaine acts as
a methyl donor and supports the methylation detoxification
pathway. Betaine assists in the conversion of homocysteine to
methionine as well as increasing s-adenosylmethione (SAMe)
levels. This prevents fat infiltration in the liver and protects
against the free radical stress generated by toxic chemicals. 
2-3 capsules two times per day or as recommended by your
health care professional.
Does Not Contain
Gluten, yeast, artificial colors and flavors.
Do not consume this product if you are pregnant or nursing.
Consult your physician for further information.
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Molecular mechanisms of DNA damage and repair:
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2. Huffman MA. Animal self-medication and ethnomedicine:
exploration and exploitation of the medicinal properties
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3. Bosisio E, Benelli C, Pirola O, et al. Effect of the
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Curcuma longa Linn. J Clin Biochem Nutr 2007; 41(1):32-42.
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