Dehydroepiandrosterone (DHEA) is a steroid hormone
precursor, which helps maintain healthy hormone levels and
helps support the stress response system. DHEA functions as
the counterpart to the stress hormone cortisol. Maintaining
healthy DHEA levels is crucial for balancing the catabolic
effects of cortisol. Each capsule provides 25 mg of DHEA
derived from the wild yam, allowing for incremental oral
supplementation and flexibility with numerous hormone
balancing and stress-fighting protocols.
DHEA is a steroid hormone secreted primarily by the adrenal
glands and, to a lesser extent, by the testes and ovaries.
DHEA and its sulfate, DHEAs, are the most abundant steroid
hormones in the human body and can be found in blood,
saliva, urine and cerebrospinal fluid (CSF).  DHEA serves as
a “buffer” reservoir to be used for the intracellular synthesis
of various estrogens and androgens throughout the human
body. DHEA production peaks during the second decade of
life. Beginning in the early 30s, DHEA levels typically decline by
10% per decade. In addition to the normal decline associated
with aging, other possible causes of a decline in DHEA
production include inflammation, blood sugar imbalances, as
well as long-term stress.
Secretion of DHEA is affected by pituitary adrenocorticotropic
hormone (ACTH) secretion. In addition to being a precursor
for sex hormone formation, DHEA also serves as a cortisol
antagonist, providing inflammatory balance and protection to
brain tissues from free radical stress. It is especially important
in the hippocampus, where excessive cortisol secretion can
affect mood regulation and memory. DHEA has been shown
to reverse classic stress-induced physiological responses and
support healthy aging. DHEA supplementation is particularly
important for those that have been found to be deficient
through testing, as well as those that need cortisol to DHEA
Elevated cortisol levels can play a major role in normal mood
regulation. DHEA counterbalances high levels of cortisol
and also brightens mental outlook. DHEA can easily cross
the blood-brain barrier, which is crucial for supporting brain
function. Supplementation with DHEA has been shown to
support mood regulation by increasing levels of ß-endorphins,
quieting glutamate (N-methyl-D-aspartate) receptors and
protecting against the effects of glucocorticoids in the brain. [2,3] In a
double-blind, placebo-controlled trial involving 145 subjects,
administration of DHEA for 8 weeks was found to have a
positive effect in supporting mood regulation in 56% (43 of
77) of subjects who received DHEA versus 31% (21 of 68) of
subjects in the placebo group. 
DHEA has been examined in numerous studies for its role in
supporting bone health. In a double-blind, placebo-controlled
study using 50mg/day, DHEA supplementation improved
bone turnover and decreased osteoclast activity in women
older than 70 years.  An additional randomized placebocontrolled
trial of 225 healthy women (ages 55 to 85 years)
showed that oral dosing of 50 mg/day of DHEA for one year
showed positive effects on markers of bone health. Possible
theories regarding DHEA’s ability to support bone health
include DHEA functioning as a precursor for the formation
of estradiol and androgens, which promotes healthy bone
formation by increasing levels of insulin-like growth factor. 
DHEA has been shown to support inflammatory balance by
inhibiting the activation of nuclear factor-kß and the secretion
of inflammatory compounds such as IL-6 and IL-2.
Supporting healthy inflammatory balance has been shown
to be crucial in patients with gastrointestinal (GI) challenges.
In a study involving 20 patients with GI challenges given 200
mg/day of DHEA for 56 days, 12 of 20 patients demonstrated
a significant improvement in well-being, specifically related to
inflammatory pathways that affect GI health. 
Research has indicated that DHEA naturally supports healthy
aging. In a study of 75 healthy subjects, aged 90 to 106 years,
a correlation between DHEA levels and well- being was
examined. It was found that in elderly men, those with the
highest DHEA levels had the highest level of functioning. 
An additional study examined 280 healthy individuals ages
60 to 79 years. In this study, it found that oral doses of 50
mg of DHEA per day supported bone health and libido. DHEA
supplementation also improved skin health, in the areas of
hydration, epidermal thickness and pigmentation, particularly
in female participants over 70 years of age. 
DHEA is a precursor to estrogen and testosterone. In addition,
DHEA may also have physiological actions unrelated to its
function as a hormone precursor, as DHEA receptors are also
present in human muscle cells. Clinical studies using oral
doses of DHEA have demonstrated its ability in maintaining
hormonal balance. In a study which included 20 women
(ages 50-65 years) receiving 25mg/day for 12 months, DHEA
promoted hormonal balance as soon as 3 months of DHEA
administration. As indicated by serum concentrations, DHEA
helped support healthy levels of testosterone, progesterone,
estrone and estradiol. 
1 capsule per day or as recommended by your health care
Does Not Contain
Gluten, yeast, artificial colors and flavors.
Do not consume this product if you are pregnant or nursing.
Consult your physician for further information.
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neuropsychiatric effects of dehydroepiandrosterone (DHEA) and
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2. Wolkowitz OM, Reus VI, Roberts E, et al. Dehydroepiandrosterone
(DHEA) treatment of depression. Biol Psychiatry 1997;41:311-318.
3. Genazzani AR, Stomati M, Bernardi F, et al.
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4. Rabkin JG, McElhiney MC, Rabkin R, McGrath PJ, Ferrando SJ.
Placebo-controlled trial of dehydroepiandrosterone (DHEA) for
treatment of nonmajor depression in patients with HIV/AIDS. Am
J Psychiatry 2006;163(1):59-66.
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(DHEA), DHEA sulfate, and aging: contribution of the DHEAge
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