Core Support by Ortho Molecular Products
- Enhances Liver Detoxification
- Provides Macronutrients, Phytonutrients, and Cofactors that Support Detoxification of Xenobiotics and Xenoestrogens
- Supports Healthy Estrogen Metabolism
- Increases Antioxidant Protection and Glutathione Production
- Promotes Gastrointestinal Health
Core Support was created as part of the Core Restore kit
. Core Restore supports Phase II liver detoxification by providing protein, fiber and nutrients to help eliminate toxins from the body.
Overview of Detoxification†
The human body is exposed to a wide variety of toxins on a daily basis, including chemicals found in foods, environmental toxins and pharmaceuticals. The liver is the body’s main detoxification organ which provides enzyme systems that safely process and remove xenobiotics (foreign chemical substances) out of the body, as well as unhealthy hormone metabolites. These detoxification systems are very complex and require a variety of nutrients for optimal function. There are two main pathways of detoxification in the liver, known as Phase I and Phase II. In Phase I, composed mainly of cytochrome P450 enzymes, non-reactive compounds undergo specific reactions which use oxygen to form a reactive site on the compound. Most pharmaceuticals are metabolized through Phase I biotransformation. This prepares the metabolite for the next step of detoxification knows as Phase II. Phase II is a crucial step- if molecules from Phase I are not fully metabolized by Phase II conjugation, they may cause free radical damage to proteins, RNA and DNA within the cell. Phase II reactions result in the biotransformation of fat-soluble compounds into water-soluble compounds that can then be excreted in the urine, bile or stool. The ingredients included in Core Support were chosen for their ability to support one of the six pathways of Phase II detoxification. N-acetyl cysteine, along with glycine and taurine, is a well-known amino acid that plays a role in supporting the liver. Antioxidants such as lipoic acid, green tea, ellagic acid and the vegetable antioxidant blend provide a synergistic approach to liver support and promote enhanced detoxification.
N-acetyl cysteine (NAC) is a sulfhydryl-containing amino acid that is commonly used to support liver health. Though studies have shown the absorption of oral glutathione to be limited, supplementation with NAC has been shown to significantly increase circulating levels of glutathione, a primary antioxidant that protects cellular health. [1-3] Increasing glutathione levels increases the production of specialized antioxidant enzymes, such as glutathione peroxidase, glutathione reductase and detoxification enzymes such as glutathione S-transferase. Through the activity of these enzymes, NAC protects the body from oxidative damage, increases Phase II detoxification, and enhances the normal breakdown of toxins and other metabolic by-products of the body.
One of the six Phase II detoxification pathways is amino acid conjugation (the attachment of amino acids to a toxin). Glycine is one of the amino acids used in this process. Glycine also aids in glutathione conjugation. Glycine preserves intracellular glutathione concentration and protects cells from oxidative damage. This process is mediated by a protein called glycine transporter 1, or GLYT1. Research has shown that glycine treatment of human intestinal cells against an oxidative agent, reduced the intracellular concentration of reactive oxygen species (ROS) when exposed to oxidative challenge.
The sulfation pathway is another important Phase II
detoxification pathway. During the sulfation pathway, a
sulfur-containing molecule is attached to the toxin in order to
produce a compound that can be excreted out of the body.
Studies show taurine effectively conjugates bile acids  and
protects the liver against toxic heavy metals such as arsenic by
supporting gluthathione levels in the liver. 
Lipoic acid is a potent antioxidant that has been shown
to increase glutathione, vitamin E and vitamin C levels in
the body. Lipoic acid has been shown to support Phase II
detoxification by increasing the activity of enzymes including
NAD(P)H, quinine oxidoreductase, and glutathione-Stransferase.
Lipoic acid has been used to detoxify mycotoxins
(toxic by-products produced by fungi and molds). Lipoic acid
has also been shown to reverse age-related loss of glutathione
Green Tea Extract†
Green tea is one of the most widely consumed beverages
throughout the world for its health- promoting benefits. One of
the main polyphenols in green tea includes epigallocatechin-
3-gallate (EGCG). Green tea polyphenols have demonstrated
significant antioxidant- and inflammatory- balancing effects.
Green tea has also been shown to provide Phase II stimulating
properties. Studies have shown that green tea extract
increases Phase II enzymes such as glutathione transferase,
NAD(P)H, quinine reductase, epoxide hydrolase, and UDPglucuronosyltransferase.
EGCG potentiates cellular defense
capacity against chemical toxins, ultraviolet radiation, and
oxidative stress. 
Rosemary includes polyphenols that are potent antioxidants,
which provide a significant boost to immune response and upregulate
detoxification mechanisms of the liver.  Carnosol,
an antioxidant in rosemary, induces glutathione-s- transferase,
as well as other important Phase II enzymes.  Rosemary
essential oil and carnosol have also been shown to increase
intracellular glutathione levels. 
Vegetable Antioxidant Blend†
Core Support contains VitaVeggie®, a blend of highconcentration
superfood vegetables with significant
antioxidant potential. VitaVeggie® is high in ORAC value
(oxygen radical absorbance capacity- a method of measuring
antioxidant activity) and includes health promoting compounds
like sulphoraphane and glucosinolates. Cruciferous vegetables
including broccoli, kale, and Brussels sprouts increase the
enzyme activity of both Phase I and Phase II detoxification
pathways.  Sulforaphane induces Phase II detoxification
enzymes and supports the body’s response to oxidative stress
to promote balanced inflammation.  Glucosinolates serve as
precursors for biologically active metabolites, which induce
Phase II enzymes via the activation of Nrf2, the master cellular
switch responsible for antioxidant production.
Schizandra Berry Extract†
Schizandra is an adaptogenic botanical used medicinally
to help fight off the physical and mental effects of stress.
Schizandra is also used to support liver health and neutralize
the effects of toxin exposure. Schizandra enhances liver
detoxification pathways by increasing the levels of reduced
glutathione in the liver as well as glutathione reductase and
glutathione S-transferase activity. In animal studies, schizandra
has been shown to support Phase I metabolism and protect
the liver from free radical damage induced by toxic chemical
exposure following ingestion of carbon tetrachloride. 
Psyllium husk is from the plant Plantago ovata and has a large
amount of soluble fiber per volume. Psyllium is used to improve
gastrointestinal transit time and promotes cardiovascular
health by maintaining normal cholesterol levels through the
elimination of cholesterol-rich bile. Studies show psyllium husk
powder up-regulates genes involved in bile acid synthesis and
binds to bile-acids in the intestines to gently remove them
from the body. [21, 22]
Mix 2 scoops (39.0 grams) of Core Support with 8 oz. of
water or the beverage of your choice two times daily, or as
recommended by your health care professional.
Does Not Contain
Gluten, yeast, artificial colors and flavors.
Do not consume this product if you are pregnant or nursing.
Consult your physician for further information.
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