What is the Core Restore Kit?
The Core Restore Kit is a strategic system designed to safely
enhance and promote the primary pathways of detoxification
in the liver. The Core Restore Kit provides three active formulas
– Core Support, Alpha Base, and PhytoCore – which function
synergistically to support Phase I and Phase II pathways of liver
detoxification to help neutralize environmental pollutants,
hormone disruptors, unhealthy estrogen metabolites,
xenoestrogens (synthetic compounds that imitate estrogen),
and other harmful toxins. This powerful trio of specialized
formulas provides essential micronutrients, phytonutrients,
and a source of easily digested, low- allergen protein that
purify the liver and fuel optimal biotransformation. The Core
Restore Kit is an easy-to-follow, 7-day program designed to
reduce the incoming burden of toxins to restore
Overview of Detoxification†
Our increasingly toxic world creates a major burden on our
bodies. Exposure through the air we breathe, the stress we
feel and the food we ingest can add up to over 14 pounds
of pesticides, herbicides, food additives and preservatives per
year for the average American. The liver, together with the
gastrointestinal (GI) tract, is the organ responsible for removing
these toxins through a process called biotransformation. If the
liver is not working at full speed, every other system in the
body is at risk as fat soluble toxins, which are poorly excreted,
become stored in the body. The process of biotransformation
is performed through a two-step enzymatic process known as
Phase I and Phase II detoxification.
These two pathways help to breakdown toxins into harmless
substances. Phase I is composed of a series of enzymes, called
cytochrome P450, which chemically change harmful, fatsoluble
toxins into more toxic substance called intermediate
metabolites.  Since the “intermediary metabolites” are often
more toxic than the original fat- soluble toxin, they must then
go through Phase II processing into safe and water soluble
form through their attachment to other molecules, to form
inert compounds which are then safely released from the
body. The Core Restore Program is a science based system
strategically designed to enhance Phase II mechanisms first,
ensuring proper clearance of toxins, then provides nutritional
support for Phase I detoxification making sure each step of
biotransformation is in sync and reducing the toxic burden on
Products Included in the Core
Core Support powder enhances Phase II detoxification by
providing clean protein, gentle fiber, and specific nutrients
which help eliminate toxins during the 7-day detoxification
program. Core Support provides nutrients needed for Phase II
detox including N-acetyl cysteine, glycine, taurine, lipoic acid,
green tea extract, ellagic acid, and a unique blend of vegetable
phytonutrients. The antioxidant activity of this unique blend of
nutrients is protective against cell damage by free radicals and
helps induce Phase II enzymes which facilitate the removal of
toxins from the body and scavenge free radicals.  Research has
shown that glutathione and the amino acid cysteine help to
regulate Phase II conjugation reactions  and epigallocatechin-
3-gallate (EGCG), the major polyphenol in green tea, has also
been shown to induce expression of glutathione S-transferase
and glutathione peroxidase.  Core Support provides 15g of
organic brown rice protein as a satisfying and hypoallergenic
energy source, as well as 5g of fiber per serving, essential for
binding toxins for elimination.
Mix 2 scoops (39.0 grams) of Core Support with 8 oz. of water or
the beverage of your choice 2 times daily or as recommended
by your health care professional.
Without drinking enough liquid, this product may swell in
throat, causing blockage or choking. DO NOT use if you have
ever had esophageal narrowing or swallowing difficulties. Seek
immediate medical help if symptoms of esophageal blockage
(chest pain/pressure, regurgitation or difficulty swallowing)
occur. May cause allergic reaction in persons sensitive to
inhaled or ingested Psyllium.
Phytocore is added on the third day of the Core Restore
program to stimulate Phase I activity once Phase II has been
established. The specialized blend of nutrients in Phytocore
has been shown to stimulate Phase I and II biotransformation
and support the body’s natural liver cleansing function during
detoxification. Each capsule includes silymarin, artichoke
extract, curcumin, methionine, choline, inositol, garlic, and
dandelion root. These botanicals and plant extracts include
phytonutrients, antioxidants and other compounds that protect
plants from environmental challenges including exposure
to radiation and toxins, and defend them against pests and
infectious agents. In humans, this array of biologically active
compounds has been shown to increase cellular defenses,
upregulate detoxification, and protect DNA. [6,7]
Silymarin has been found to possess substantial protective
effects and free radical scavenging capacity, protecting the
liver against oxidative damage while it neutralizes toxic
environmental contaminants.  Curcumin, another compound
in Phytocore, has also been linked with increased expression
of the detoxification enzymes glutathione-s-transferases,
glutathione reductase, epoxide hydrolase, HO-1, catalase and
NQO1 in liver, small intestine and kidney tissues. 
2-3 capsules two times per day or as recommended by your
health care professional.
Alpha Base provides a multi-nutrient foundation to ensure the
liver has adequate amounts of important trace minerals and
vitamins needed for the energy/nutrient intensive process
of detoxification. Nutrients such as vitamin C, vitamin E, and
the B vitamins are required for cytochrome P450 activity.
In addition to vitamins and trace minerals, carotenoids are
included to help scavenge free radicals and protect cells while
toxins are removed.
4 capsules per day as part of the Core Restore Program, or as
recommended by your health care professional.
All forms of Vitamin K may interact with blood thinning
medications. If you are taking such medicines please consult
with your physician before taking this product.
Product Data Sheet: Core restore Detox Support Flyer from Ortho Molecular Products
1. Liska, D. J. The detoxification enzyme systems. Altern Med
Rev. 1998; 3(3):187-198.
2. Liska, D., Lyon, M. et al. Detoxification and
Biotransformational Imbalances. 2005;(22):275-298.
3. Wattenberg LW. Inhibition of carcinogenesis by minor
dietary constituents. Cancer Res (Suppl) 1992;52:
4. Bland JS. Detoxification and rejuvenation. The 20-day
rejuvenation diet program.1997:105-120.
5. HK, Surh YJ. Modulation of Nrf2-mediated antioxidant and
detoxifying enzyme induction by the green tea
polyphenol EGCG. Food Chem Toxicol. 2008 Apr;46(4):1271-
8. Epub 2007 Oct 17. Na.
6. Tuteja N, Singh MB, Misra MK, Bhalla PL, Tuteja R.
Molecular mechanisms of DNA damage and repair:
progress in plants. Crit Rev Biochem Mol Biol 2001;36:337–
7. Huffman MA. Animal self-medication and ethnomedicine:
exploration and exploitation of the medicinal
properties of plants. Proc Nutr Soc 2003;62:371–381.
8. Kiruthiga PV, Shafreen RB, Pandian SK, Devi KP. Silymarin
protection against major reactive oxygen species
released by environmental toxins: exogenous H2O2
exposure in erythrocytes. Basic Clin Pharmacol Toxicol.
9. Shen G, Xu C, Hu R, Jain MR, et al. Modulation of nuclear
factor E2-related factor 2-mediated gene expression in
mice liver and small intestine by cancer chemopreventive
agent curcumin. Mol Cancer Ther 2006;1:39–51.