What is CoQ10?
Coenzyme Q10 (CoQ10), also known as ubiquinone, is a
proenzyme produced naturally within the body. CoQ10 plays
a critical role in energy (ATP) production and is one of the
most powerful known lipidsoluble antioxidants, protecting
cells, organs and tissues from damage caused by oxidative
stress and free radicals. CoQ10 inhibits protein and lipid
oxidation and protects mitochondrial DNA from oxidative
damage. This CoQ10 formulation is delivered in an oilbased
proprietary form and includes natural vitamin E for
enhanced absorption and maximum stability.
CoQ10 is a lipid-soluble antioxidant found in every cell in the
body. CoQ10 is abundant in the mitochondrial membrane
and plays an important role in the synthesis of adenosine
triphosphate (ATP), a molecule of chemical energy upon which
all cellular functions depend. The synthesis of ATP within the
mitochondria is a multi-step series of biochemical reactions
called the electron transport chain. As a coenzyme, CoQ10 is
required for several enzymatic reactions required to produce
cellular energy and to protect the body against free radicals
produced during this process. To maintain energy production,
mitochondrial CoQ10 is continuously recycled from ubiquinone,
its ATP production state, to ubiquinol, its antioxidant state.
After the age of 35 to 40 years, endogenous synthesis of
CoQ10 begins to decline.1
CoQ10, an essential component of
cellular energy production, has been shown to extend cell life
and benefit high-energy systems, namely the cardiovascular,
neurological and immune systems.
The body’s ability to produce and metabolize CoQ10 has been
reported to decrease with age. CoQ10 deficiency may be
caused by insufficient dietary intake of CoQ10, impairment
in CoQ10 production, drug-induced CoQ10 depletion, gene
mutations and oxidative stress. HMG-CoA reductase is an
enzyme required for the synthesis of cholesterol and CoQ10.
Cholesterol lowering medications inhibit this enzyme in order
to reduce cholesterol synthesis, but may also simultaneously
deplete CoQ10 status. Thirteen controlled studies conducted
between 1990-2004 demonstrated significant CoQ10 depletion,
secondary to use of statin medications used to lower
These studies demonstrated a range of 19-
54% decrease in CoQ10 levels in patients on statin therapy. In
the event of CoQ10 depletion, supplementation can improve
CoQ10 status and help maintain optimal levels in the body.
Oxidative stress is a condition that occurs when there is an
imbalance between free radicals and the antioxidants required
to neutralize them, leading to oxidative damage in the body.
The extent of oxidative stress depends on the rate of free
radical generation, the level of antioxidant reserves and the
rate of repair of cellular and tissue damage. This process has
a significant impact on the body’s aging process. In its role
in electron transport, CoQ10 continuously goes through an
oxidation-reduction cycle in order to neutralize free radicals
and provide significant protection against toxic oxidative
reactions in the body.
CoQ10 is important for all energy-dependent processes, and
is especially helpful in strengthening contraction of the heart
muscle. CoQ10 is also important for protection against free
radical damage to the arterial vessels. In a double-blind, crossover
trial 19 patients received 100 mg CoQ10/day or placebo for
12 weeks. Compared with placebo, patients receiving CoQ10
demonstrated significant support of cardiac function and
increased tolerance for physical activity.3
In another study, 109
patients received an average dose of 225 mg of CoQ10 per day.
After a mean treatment period of 4.4 months, CoQ10 helped in
maintaining healthy blood pressure levels in more than half of
CoQ10 has been shown to be a preventive factor
in reducing low-density lipoprotein (LDL) oxidation- a major
factor for supporting healthy cholesterol levels.5
Blood Sugar Balance†
The electron transport chain, a biochemical pathway in which
CoQ10 plays a major role, significantly impacts carbohydrate
metabolism. CoQ10 has been shown to support healthy blood
sugar metabolism.7 In one study, 39 subjects received 120mg
of a CoQ10 analog for 2-18 weeks. Fasting blood sugar levels
were maintained in the normal range, along with a 30%
decrease of ketone bodies in 59% of patients- an indicator of
healthy blood sugar metabolism.8
Neurons are characterized by high rates of metabolic activity
and the need to respond quickly to energy demanding
fluctuations in the brain. Mitochondrial alterations, leading to
reduced ATP production, can promote neuronal dysfunction
and degeneration via increased production of reactive oxygen
species in the central nervous system. As an effective carrier
with strong antioxidant properties, CoQ10 has been shown to
support neurological health.9
1. Hojerova J. Coenzyme Q10- its importance, properties
and use in nutrition and cosmetics. Ceska Slov Farm
2. Hargreaves IP, Duncan AJ, Heales SJ, Land JM. The effect
of HMG-CoA reductase inhibitors on coenzyme Q10:
possible biochemical/clinical implications. Drug Saf
3. Langsjoen PH, Vadhanavikit S, Folkers K. Effective
treatment with coenzyme Q10 of patients with chronic
myocardial disease. Drugs Explt Clin Res 1985;11:577-579.
4. Langsjoen P, Langsjoen P, Willis R, Folkers K. Treatment of
essential hypertension with Coenzyme Q10. Molec Aspects
5. Stocker R, Bowry VW, Frei B. Ubiquinol-10 protects
human low density lipoprotein more efficiently against
lipid peroxidation than does alpha-tocopherol. Proc Natl
Acad Sci 1991; 88(5):1646-50.
6. Gaby AR. The role of coenzyme q10 in clinical medicine:
Part II. Cardiovascular disease, hypertension, diabetes
mellitus and infertility. Altern Med Review 1996; 1(3):168-
7. Shigeta Y, Izumi K. Abe H. Effect of coenzyme Q7
treatment on blood sugar and ketone bodies of diabetics.
J Vitaminol 1966;12:293-298.
8. Mancuso M, Orsucci D, Calsolaro V, Choub A, Siciliano G.
Coenzyme Q10 and Neurological Diseases. Pharmaceuticals