CM Core by Ortho Molecular Products
CM Core® provides multidimensional support for cardiovascular health by helping to support healthy cholesterol levels and normal blood pressure.
- Multidimensional Support for Cardiovascular Health
- Maintains Healthy Cholesterol Levels
- Helps Maintain Healthy Blood Sugar Balance
- Supports Normal Blood Pressure
CM Core, a formula backed by extensive clinical research,
is designed to address several factors associated with
ideal cardiometabolic health. The powerful combination
of berberine and alpha lipoic acid (ALA) helps maintain
heart function, metabolism, antioxidant status, and
lipid and glucose levels. CM Core provides a powerful
formula for those seeking to optimize the multiple
mechanisms of cardiovascular and metabolic health.
Clinical research shows that maintaining optimal cardiovascular
health should address multiple metabolic factors such as
blood sugar support, lipid balance, inflammatory balance,
metabolic efficiency, and antioxidant status.1
CM Core’s unique
formula offers multidimensional support for these aspects
of cardiovascular health. Among their numerous benefits,
berberine and alpha lipoic acid activate the master metabolic
switch, adenosine mono-phosphate kinase (AMPK). Activation
of this powerful metabolic enzyme triggers a variety of genes
that help improve metabolism, stabilize mitochondria, and
enhance insulin sensitivity.3,4
Berberine is a plant extract that has been used in Chinese and
Ayurvedic medicine for over 2,500 years for its broad range
of health-promoting properties. Berberine can be found in
the roots and stems of plants such as Hydastatis Canadensis
(goldenseal), Coptis chinensis (goldenthread), Berberis
aquifolium (Oregon grape) and Berberis vulgaris (barberry).
Clinical trials have demonstrated that berberine administration
supports cardiovascular health in a number of synergistic
ways including maintaining blood pressure, supporting
healthy heart contraction and rhythm and supporting
healthy cholesterol levels.5,6 A clinical trial with 32 subjects
demonstrated that administration of 500 mg of berberine
given twice daily for three months helped maintain healthy LDL
cholesterol and triglyceride levels, versus the control group.7
Another recent study using 500 mg of berberine was able to
produce similar results, confirming berberine’s powerful effect
on specific cardiovascular markers including LDL cholesterol,
HDL cholesterol and triglyceride levels.8
In addition to maintaining healthy lipid levels, berberine
has also been shown to maintain healthy blood glucose
levels through activation of AMPK.9
AMPK coordinates both
long-term and short-term metabolic changes, leading to
an improvement in energy production and a reduction of
energy storage. AMPK improves insulin sensitivity, and downregulates
genes involved in fat storage while activating genes
involved with burning fat.3
Activation of AMPK has been shown
to stimulate the transcription factor involved in replicating
mitochondria for increased metabolic potential.10
Berberine has also been shown to promote the uptake of
glucose through a mechanism that does not require insulin,
promoting better glucose usage within the cell.11 A study
examining berberine’s metabolic supporting effects found
that berberine improved glucose tolerance and maintained
balanced insulin levels, while helping to maintain healthy total
cholesterol and triglyceride levels after four weeks of berberine
Alpha Lipoic Acid†
Alpha lipoic acid (ALA) is a nutrient required for cellular
metabolism, specifically the breakdown of carbohydrates and
fatty acids.13 ALA has been shown to support blood sugar
balance by activating AMPK, a major regulator of cellular
energy.14 A study using a dose of 600 mg/day of ALA over
three months demonstrated that ALA helps support healthy
lipid levels while improving oxidative stress (reducing free
radical damage) by 38%.15 An additional study examining the
effects of ALA on 74 subjects found that within the four-week,
placebo-controlled trial, administration of 600 mg of ALA per
day significantly enhanced glucose transport and utilization.16
ALA is also a potent antioxidant. It scavenges free radicals
while aiding in the regeneration of the body’s antioxidants
including vitamin C, vitamin E and glutathione.17 Through its
antioxidant-boosting mechanisms, ALA helps maintain healthy
blood vessel and circulatory health.
3 capsules per day or as recommended by your health care
Does Not Contain
Does not contain gluten, corn, yeast, animal or dairy products,
artificial colors, artificial flavors or preservatives.
If you are pregnant or nursing, consult your health care
professional before taking this product.
1. Grundy SM, Cleeman JI, Daniels SR, Donato KA, Eckel RH,
Franklin BA, Gordon DJ, Krauss RM, Savage PJ, Smith SC.
Diagnosis and management of the metabolic syndrome
an american heart association/national heart, lung,
and blood institute scientific statement. Circulation.
2. Jeong HW, Hsu KC, Lee J-W, Ham M, Huh JY, Shin HJ, Kim
WS, Kim JB. Berberine suppresses proinflammatory
responses through ampk activation in macrophages.
American Journal of Physiology-Endocrinology And
3. Kemp B, Stapleton D, Campbell D, Chen Z-P, Murthy S,
Walter M, Gupta A, Adams J, Katsis F, van Denderen B.
Amp-activated protein kinase, super metabolic regulator.
Biochemical Society Transactions. 2003;31:162-168.
4. Towler MC and Hardie DG. AMP-activated protein kinase in
metabolic control and insulin signaling. Circulation research.
5. Lau CW, Yao XQ, Chen ZY, Ko WH and Huang Y.
Cardiovascular actions of berberine. Cardiovascular Drug
6. Brusq J-M, Ancellin N, Grondin P, Guillard R, Martin S,
Saintillan Y and Issandou M. Inhibition of lipid synthesis
through activation of AMP kinase: an additional mechanism
for the hypolipidemic effects of berberine. Journal of lipid
7. Kong W, Wei J, Abidi P, Lin M, Inaba S, Li C, Wang Y, Wang Z,
Si S and Pan H. Berberine is a novel cholesterol-lowering
drug working through a unique mechanism distinct from
statins. Nature medicine. 2004;10:1344-1351.
8. Derosa G, D’Angelo A, Bonaventura A, Bianchi L, Romano
D and Maffioli P. Effects of berberine on lipid profile in
subjects with low cardiovascular risk. Expert opinion on
biological therapy. 2013;13:475-482.
9. Zhang H, Wei J, Xue R, Wu J-D, Zhao W, Wang Z-Z, Wang
S-K, Zhou Z-X, Song D-Q and Wang Y-M. Berberine lowers
blood glucose in type 2 diabetes mellitus patients through
increasing insulin receptor expression. Metabolism.