Bergamot Bioactive Polyphenolic Fractions (BPF) contains
a powerful and unique array of cholesterol-balancing and
cardio-protective polyphenolic flavonoids.
research has demonstrated that BPF help maintain:
total cholesterol (TC),
- high density lipoprotein (HDL),
density lipoprotein (LDL),
- very low density lipoprotein (VLDL) levels,
- very low density triglyceride (TRI) levels.
Research has also demonstrated
that BPF provides antioxidant and inflammatory balancing
properties to help preserve coronary arteries.
Optimizing cardiovascular health is a leading concern for
many adults, and maintaining balanced cholesterol levels are
an important part of that process. Though cholesterol can be
consumed through food, circulating cholesterol levels are
primarily produced and controlled by the liver using the rate
control enzyme, HMG-CoA reductase (HMGCR). Because of its
pronounced role in cholesterol synthesis, inhibiting HMGCR
has become a primary target of many traditional therapies.
Numerous clinical trials have shown the specific BPF found in
Bergamot BPF works at the level of the liver to help maintain
and support healthy cholesterol levels and preserve coronary
arteries by maintaining inflammatory balance.
What are Bergamot Polyphenolic Fractions?
Bergamot (Citrus bergamia) is a citrus plant that grows almost
exclusively in the narrow coastal Calabria region in southern
Italy. The local population quickly discovered bergamot juice
could be used to help support healthy cholesterol levels and
optimize cardiovascular wellness.
Bergamot’s health benefits derive from its unique profile of
phenolic compounds such as, neoeriocitrin, neohesperidin,
naringin, rutin, neodesmin, rhoifolin and poncirin. Naringin
has been shown to be beneficial in maintaining inflammatory
balance in arteries, while neoeriocitrin and rutin have been
found to exhibit a strong capacity to quench free radicals and
maintain healthy LDL cholesterol levels. Also, bergamot is rich
in brutieridine and melitidine, which have a unique ability to
dampen HMG-CoA reductase.
Using a patented extraction technology through collaborative
works of various universities and research institutions, Bergamot
BPF contains Bergamonte®, the highest concentration available
of these potent phenolic compounds.
In a placebo-controlled, clinical trial consisting of 77 patients
divided into four treatment groups, 1,000 mg of BPF helped
maintain healthy levels of all blood lipid markers (HDL, LDL,
Also, this same clinical trial showed that BPF activated
the inflammatory-balancing enzyme AKT and reduced
malondialdehyde production in neutrophils.1
trial conducted on 80 patients over six months showed 150
mg of BPF maintained normal levels of small density LDL and
reduced carotid IMT by 25%.2
In a placebo-controlled study
involving 238 patients, 1,000 mg of BPF maintained healthy
cholesterol levels and outperformed the group receiving
the traditional therapy.3
Following a 60-day wash out phase
in patients who had been on traditional therapies, 1,500 mg
of BPF maintained normal LDL levels and optimized several
other parameters of cardiovascular health.3
recently published placebo-controlled clinical trials have also documented that BPF can help support normal inflammatory
balance, antioxidant potential, healthy cholesterol levels, and
CoQ-10 levels in humans.4-12
2 capsules per day or as recommended by your health care
Does Not Contain
Gluten, corn, yeast, artificial colors and flavors.
If you are pregnant or nursing, consult your health care
professional before taking this product.
1. Gliozzi M, Walker R, Muscoli S, Vitale C, Gratteri S, Carresi
C, Musolino V, Russo V, Janda E and Ragusa S. Bergamot
polyphenolic fraction enhances rosuvastatin-induced
effect on LDL-cholesterol, LOX-1 expression and protein
kinase B phosphorylation in patients with hyperlipidemia.
International journal of cardiology. 2013;170:140-145. Abstract
2. Toth PP, Patti AM, Nikolic D, Giglio RV, Castellino G,
Biancucci T, Geraci F, David S, Montalto G and Rizvi A.
Bergamot Reduces Plasma Lipids, Atherogenic Small
Dense LDL, and Subclinical Atherosclerosis in Subjects with
Moderate Hypercholesterolemia: A 6 Months Prospective
Study. Frontiers in pharmacology. 2015;6. Article
3. Mollace V, Sacco I, Janda E, Malara C, Ventrice D, Colica C,
Visalli V, Muscoli S, Ragusa S and Muscoli C. Hypolipemic
and hypoglycaemic activity of bergamot polyphenols:
from animal models to human studies. Fitoterapia.
4. Di Donna L, Iacopetta D, Cappello AR, Gallucci G, Martello
E, Fiorillo M, Dolce V and Sindona G. Hypocholesterolaemic
activity of 3-hydroxy-3-methyl-glutaryl flavanones
enriched fraction from bergamot fruit (Citrus bergamia):“In
vivo” studies. Journal of Functional Foods. 2014;7:558-568. PDF Article
5. Campolongo G, Riccioni CV, Raparelli V, Spoletini I, Marazzi
G, Vitale C and Volterrani M. The combination of
nutraceutical and simvastatin enhances the effect of
simvastatin alone in normalising lipid profile without
side effects in patients with ischemic heart disease. IJC
Metabolic & Endocrine. 2016;11:3-6. PDF Article
6. Cappello A, Dolce V, Iacopetta D, Martello M, Fiorillo M,
Curcio R, Muto L and Dhanyalayam D. Bergamot (Citrus
bergamia Risso) Flavonoids and Their Potential Benefits in
Human Hyperlipidemia and Atherosclerosis: an Overview.
Mini reviews in medicinal chemistry. 2015. Abstract
7. Giglio RV, Patti AM, Nikolic D, Volti GL, Al-Rasadi K, Katsiki
N, Mikhailidis DP, Montalto G, Ivanova E and Orekhov AN.
The effect of bergamot on dyslipidemia. Phytomedicine.
8. Janda E, Lascala A, Martino C, Ragusa S, Nucera S, Walker
R, Gratteri S and Mollace V. Molecular mechanisms of lipidand
glucose-lowering activities of bergamot flavonoids.
PharmaNutrition. 2016. PDF Article
9. Mollace V, Ragusa S, Sacco I, Muscoli C, Sculco F, Visalli V,
Palma E, Muscoli S, Mondello L and Dugo P. The protective
effect of bergamot oil extract on lecitine-like oxyLDL
receptor-1 expression in balloon injury-related neointima
formation. Journal of cardiovascular pharmacology and
therapeutics. 2008;13:120-129. Abstract PDF Article
10. Risitano R, Currò M, Cirmi S, Ferlazzo N, Campiglia P,
Caccamo D, Ientile R and Navarra M. Flavonoid fraction
of Bergamot juice reduces LPS-induced inflammatory
response through SIRT1-mediated NF-?B inhibition in
THP-1 monocytes. PLoS One. 2014;9:e107431. Article
11. Trombetta D, Cimino F, Cristani M, Mandalari G, Saija A,
Ginestra G, Speciale A, Chirafisi J, Bisignano G and Waldron
K. In vitro protective effects of two extracts from bergamot
peels on human endothelial cells exposed to tumor
necrosis factor-a (TNF-a). Journal of agricultural and food
chemistry. 2010;58:8430-8436. PDF Article
12. Benson J. ALTERNATIVE MEDICINE CABINET: Bergamot.
Alternative Medicine. 2015:49. Link