Avipaxin by Neuroscience was designed to help the body decrease pro-inflammatory cytokines while normalizing cytokine-induced neurotransmitter imbalances.
How Avipaxin Works
Avipaxin supports optimal acetylcholine levels‚ which can help improve mood‚ memory‚ sleep quality and mental clarity. Pro-inflamatory cytokines that trigger imbalances in certain neurotransmitters are often associated with changes in mood and mental health. Avipaxin works to support normal brain function by using acetylcholine and the cholinergic anti-inflammatory pathway to reduce elevated pro-inflammatory cytokine levels.
Huperzine‚ which is an ingredient of Avipaxin‚ is a potent inhibitor of acetylcholinesterase (the enzyme that metabolizes acetylcholine). As it blocks acetylchoninesterase‚ circulating levels of acetylcholine are increased. Other active ingredients within Avipaxin are a-Glyceryl Phosphoryl Choline (a-GPC) and Acetyl-L-Carnitine. a-Glyceryl Phosphoryl Choline supplies choline and Acetyl-L-Carnitine supplies acetyl groups – both functions that support acetylcholine synthesis.
Much research has been done recently on the role that the vagus nerve plays in mediating immune activation. What has been found is that the cytokines that are released when the immune system is challenged‚ activate the vagal nerve‚ which results in increased cortisol levels via the Hypothalmic-Pituitary-Adrenal axis. Vagal pathways in the brain secrete acetylcholine‚ which then binds to activated immune cells and down-regulates the pro-inflammatory cytokine production of those cells.
Avipaxin works by supporting acetylcholine levels‚ which leads to a reduction of pro-inflammatory cytokines and thus a normalization of neurotransmitter concentrations.
What is Acetylcholine?
Acetylcholine was actually the first neurotransmitter to ever be discovered. It is released when the vagus nerve is stimulated‚ so it is crucial to heart muscle contractions; but it is important for the motion of other muscles as well. Acetylcholine is essential for a properly functioning memory; without it‚ you would be extremely forgetful. It has been the subject of treatment for a wide array of memory deficits‚ such as those we see with Alzheimer’s. Whether directly or indirectly‚ any mental health issue involving memory is believed to be somehow related to acetylcholine levels.
Choline is a B vitamin that is heavily concentrated in high-cholesterol foods like liver and eggs. Because high cholesterol has become such a problem in this country‚ many people avoid such foods; but end up with a short supply of choline. Without enough choline‚ you may experience memory impairment and have trouble concentrating. This is likely because your body cannot produce enough acetylcholine without enough choline. Acetylcholine is linked to memory function. In fact‚ one study shows that people who were taking acetylcholine blocking drugs are much more likely to fail memory tests. So‚ it shouldn’t be much of a surprise to learn that low levels of acetylcholine have been linked to poor memory function and also Alzheimer’s disease.