Iron is one of the most abundant minerals on earth. It is
essential to the majority of life forms, especially human
physiology. Iron supports prenatal and cognitive health, as
well as energy balance.
Iron is an integral component of the proteins involved in oxygen
transport and storage: hemoglobin, myoglobin and ferritin.
Iron, as part of the protein hemoglobin, carries oxygen from
the lungs to various parts of the body. Hemoglobin accounts
for nearly two-thirds of the iron found in the body, and carries
essential oxygen to tissues and organs. Approximately onesixth
of the body’s iron is stored as ferritin for use when dietary
intake is not sufficient.
Iron must be maintained at balanced levels within the body
– too much can cause toxicity and too little may lead to
impairment of optimal health outcomes. Iron has to be carefully
absorbed by the body. Interference can easily occur, making
adequate consumption through diet and supplementation
imperative to achieving a healthy balance. [1-8]
The importance of bioavailability is obvious. If consuming an
iron supplement has little effect on improving the body’s iron
balance, there is no reason to ingest it. Signs of inferior mineral
supplements include the use of cheap, poorly absorbed, rocksalt
minerals. Reacted Iron is formulated with the superior
amino acid chelate form, ferrous bisglycinate, which does not
ionize in the gut. Like heme iron (the most bioavailable form
of iron found in some protein food sources), Ferrochel® Ferrous
Bisglycinate is not impacted by dietary factors and is absorbed
at a 59 % higher rate than lesser forms, such as ferrous sulfate
(See Figure 1).
Comparison studies have shown significantly superior
absorption of the iron chelate form compared to other rocksalt
forms (most commonly ferrous sulfate).
- Iron from Ferrochel® iron shows absorption rates
59 % higher than ferrous sulfate
- Ferrochel® iron is absorbed at a rate 3.8 times higher
than ferrous sulfate
- Ferrochel® iron shows a reduced number of adverse
complaints compared to ferrous sulfate
- No complaints of side effects were reported by subjects
at 30 mg per serving
1. Institute of Medicine. Food and Nutrition Board. Dietary
Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron,
Chromium, Copper, Iodine, Iron, Manganese, Molybdenum,
Nickel, Silicon, Vanadium and Zinc. Washington, DC:
National Academy Press, 2001.
2. Bothwell TH, Charlton RW, Cook JD, Finch CA. Iron
Metabolism in Man. St. Louis: Oxford: Blackwell Scientific,
3. Miret S, Simpson RJ, McKie AT. Physiology and molecular
biology of dietary iron absorption. Annu Rev Nutr
4. Uzel C and Conrad ME. Absorption of heme iron. Semin
Hematol 1998;35:27-34. [PubMed abstract].
5. Sandberg A. Bioavailability of minerals in legumes. British
J of Nutrition. 2002;88:S281-5. [PubMed abstract]
6. Davidsson L. Approaches to improve iron bioavailability
from complementary foods. J Nutr 2003;133:1560S-2S.
7. Hallberg L, Hulten L, Gramatkovski E. Iron absorption
from the whole diet in men: how effective is the regulation
of iron absorption? Am J Clin Nutr 1997;66:347-56. [PubMed
8. Monson ER. Iron and absorption: dietary factors which
impact iron bioavailability. J Am Dietet Assoc. 1988;88:786-