Pregnenolone benefits are backed up by solid science:

Brain function: Pregnenolone helps raise brain levels of acetylcholine, the neurotransmitter needed for thought processes that is typically low in Alzheimers’ patients.

Memory enhancement: It can boost memory and prevent its loss.  Animal studies show it support memory-protects sleep,

Depression and anxiety: Pregnenolone can help relieve depression and anxiety. Schizophrenia patients, who are very anxious, generally have the lowest levels of pregnenolone. Several studies, including two at the University of California, San Francisco, show this.

Stress and fatigue: Pregnenolone helps counter the effects of stress to lessen fatigue and increase endurance.

Joint pain: Joint pain relief as well as rheumatoid arthritis and gout, even when conventional therapies may not help. 

PMS and menopause: Pregnenolone plays a promising role in the pathophysiology of PMS, and according to my colleague and hormone expert Ray Sahelian, M.D., it can help alleviate PMS and menopause symptoms, particularly hot flashes and loss of libido according to many researchers.

Cholesterol: In one study, pregnenolone helped decrease subjects’ total average cholesterol levels from 263.5 mg/dL to 187.9 mg/dL, suggesting that balanced hormone levels may stabilize the body’s production of excess cholesterol.

Addiction and chemical dependency: A study in the Journal of Pharmacological Science finds that pregnenolone can help combat addictive behaviors and chemical dependency. Researchers at the University of North Carolina at Chapel Hill find that pregnenolone plays an important role in alcohol tolerance and withdrawal.

Article Link including References: Pregnenole - Huff Post 

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