Glucomannan is a water-soluble dietary fiber that is derived from konjac root (Amorphophallus konjac). A meta-analysis of 14 randomized controlled trials of glucomannan found 2.0-3.87 g/day significantly balanced total blood fats, reduced body weight by 0.79 kg, and blood sugar supported healthy blood sugar levels.
Larch arabinogalactan is a fermentable polysaccharide fiber from the larch tree that supports healthy immunity by supporting the growth of beneficial gut flora, and strengthening the activity of NK cells. In one placebocontrolled, double-blind, randomized trial, Larch was found to modulate immune activity and support upper respiratory health. The same arabinogalactan-based formula was also found to boost the immune response to seasonal challenges.
Alpha Linolenic Acid
Flax seeds are a generous source of both omega-3 fatty acids and fiber. The organic flax seeds in Glycemic Foundation provide a total of 1.3 g of alpha linolenic acid per scoop, while contributing additional protein, lignans and numerous micronutrients.
Alpha Lipoic Acid
Alpha lipoic acid (ALA) is an antioxidant which has a potent effect on blood sugar metabolism. Recent studies have shown that ALAÃƒÂ¢€Ã¢â€žÂ¢s ability to regulate insulin is mediated by its activation of AMP-activated protein kinase (AMPK), which acts as a type of cellular fuel sensor to upregulate activity in the peripheral skeletal muscle; and while in the hypothalamus, downregulates AMPK, thereby, reducing appetite. Other research has found that a dose of 600 mg/day of ALA over three months lead to a 36% reduction in blood fats and a 38% improvement in the oxidative stress to oxidative defense ratio.
Chromium is a critical element in the molecule called glucose tolerance factor (GTF), a complex shown to be crucial for glucose uptake into the cells. Studies using 1,000 mcg/day of chromium showed a significant improvement in markers of blood sugar balance, insulin sensitivity and blood fats. In a study of 43 patients receiving either 600 mcg of chromium and 2 mg biotin a day or placebo, a significantly greater improvement for blood sugar was seen after four weeks, during the two hour oral sugar test.
Vanadyl sulfate (VS) stimulates glucose uptake within cells helping to use blood sugar more efficiently and maintain healthy blood sugar levels. VS increases GLUT-4 synthesis, a glucose transport protein which allows glucose to enter the cell. This improved glucose consumption promotes increased muscle cell sensitivity to insulin.